Expansion of HPV vaccine to all adults

Release embargoed until 5pm ET on Monday, November 25, 2024

@Annalsofim
Below you can find summaries of new articles to be published in the next issue of the journal. Annals of Internal Medicine. Abstracts are not intended to replace full articles as a source of information. This information is under a strict embargo and media representatives intercept it and embargo terms not only on behalf of themselves, but also on behalf of the organization they represent.
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1. Expanding the HPV vaccine to all adults aged 27-45 is unlikely to be cost-effective or effective for preventing HPV-associated cancer

Abstract:

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A modeling study predicted that HPV vaccination programs for adults ages 27 to 45 may benefit subgroups at higher risk for HPV, but overall the approach is more costly and less effective than vaccinating younger people. According to the authors, this is the first study in the United States to examine the cost-effectiveness of vaccinating subgroups of adults in this age group who are at higher risk of HPV infection and prevention of HPV-related cancer. The findings are published at: Annals of Internal Medicine.

In June 2019, the US Advisory Committee on Immunization Practices (ACIP) recommended shared clinical decision-making regarding potential HPV vaccination in adults ages 27 to 45. Researchers from Laval University in Quebec City, Quebec, used a computer model to evaluate the cost-effectiveness and number of persons (NNV) required for vaccination to prevent an HPV-related cancer if the current routine and 9-valent HPV vaccination program were completed. It has been expanded to include people ages 9-26 and adults ages 27-45. The subgroups in this age group that the model investigated were adults with higher sexual activity and people who had recently separated from a long-term partner. In all scenarios investigated, HPV vaccination of adults aged 27-25 was significantly less costly than vaccinating individuals aged 26 or younger. Additionally, NNV was significantly higher in middle adults than in those aged 26 years and younger. But the study also found that vaccinating infrequently screened middle-adult women with higher sexual activity and who were recently separated produced the lowest incremental cost-effectiveness ratio and the lowest number needed to vaccinate to prevent 1 infection compared to other subgroups. These results suggest that the cost-effectiveness of expanding HPV vaccination to older people is improved if it is limited to people at higher risk of infection. HPV vaccination of people 26 years of age and younger is significantly more cost-effective and effective than vaccinating older people.

Media contacts: For an embargoed PDF, please contact Angela Collom at [email protected]. Corresponding author Marc Brisson, PhD. To speak with, please email [email protected]. To speak with Jean-François Laprise, PhD, please email [email protected].

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2. Lack of control in the workplace causing physician burnout and attrition.

Abstract:

URL goes live when embargo is lifted

A cross-sectional study among U.S. physicians found that limited control over certain aspects of work, including schedule and workload, was associated with burnout and intention to leave one’s institution. According to the authors, this is the first study to analyze specific aspects of job control and their relationship to physician burnout and attrition. The findings may inform healthcare leaders’ strategies to reduce physician burnout and alleviate physician shortages. This study was published at: Annals of Internal Medicine.

Researchers from the American Medical Association (AMA) and colleagues examined data from the AMA Organizational Biopsy^TM From 2,339 physicians at 19 organizations between November 2022 and December 2023. They evaluated how control over specific aspects of work (patient load, clinical team structure, recruitment, schedule, workload, and areas for which physicians are responsible) affected burnout and two different career intentions. : probability of reducing the number of hours devoted to clinical care in the next 12 months (ITR) and probability of leaving their current organization within 2 years (ITL). Researchers have found that lower levels of control are associated with higher levels of burnout, ITR, and ITL. Poor control over patient volume, clinical team composition, schedule, areas of physician responsibility, and workload have each been independently associated with burnout. Lack of control over patient volume and workload were independently associated with ITR, and poor influence on recruitment, lack of control over areas for which the physician was responsible, and lack of control over workload were each associated with ITL. Given that the U.S. Health Resources and Services Administration projects a shortage of 140,000 physicians by 2036, these findings are critical for healthcare organizations to identify opportunities to reduce physician burnout and increase retention. These results suggest that ensuring physicians have adequate control over their clinical work environments should be viewed as one component of a holistic strategy to reduce burnout and retain physicians.

Media contacts: For an embargoed PDF, please contact Angela Collom at [email protected]. To speak with corresponding author Christine Sinsky, MD, please email Robert Mills at [email protected] or Jennifer Mathews at [email protected].

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There are innovations in this issue:

Ethical Approaches to Limiting the Overall Costs of GLP-1 Receptor Agonists in Weight Management

Johan Dellgren, BA; Ezekiel Emanuel, MD, Ph.D.; and Govind Persad, J.D., Ph.D.

Ideas and Opinions

Abstract:

Firearms Are Not Motor Vehicles

Kushal T. Kadakia, MSc; Behnood Bikdeli, MD, MS; Aakriti Gupta, MD; Sanket S. Dhruva, MD, MHS; Michelle Degli Esposti, PhD; Rebeccah L. Sokol, PhD; and Douglas J. Wiebe, PhD

Ideas and Opinions

Abstract:

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